Question 133



Medicine that Makes You Sick 

By Robert F. Conkling, MD, NFPMC, FCP practices family medicine in Virginia and is the co-founder of FertilityCare of the Capitol Region.

Recently three major health stories appeared in the Washington press in less than two weeks that were an occasion to pause and reflect.

First, the Potomac Conservancy made headlines about the contamination of rivers and drinking water in major metropolitan areas, including Washington, DC. Contaminants include not only bacteria, industrial chemicals and agricultural pesticides but also potentially endocrine-active pharmaceuticals, such as anti-depressants, contraceptive sex hormones, antibiotics and personal care products.

Next came the report of the US Preventive Services Task Force, an independent body which studies mortality from common diseases, issuing new guidelines for mammography screening for early detection of breast cancer. Breast cancer remains the second highest cause of mortality of American women since it began to rise in the 1970s.

Finally, the Centers for Disease Control (CDC) reported the annual statistics for sexually transmitted diseases. In 2008, there was a record number of new cases of Chlamydia—a whopping 1.2 million new cases; a rise in the number of new cases of syphilis; and an all-time record of 19 million total cases of all forms of STDs.

To connect the dots between these stories one has to ask: Could steroid–based sex hormone contraceptives be a common thread?  Hard to believe until you consider the evidence.

A Pill is Born

The first sex hormone-containing pill, a synthetic steroid called Norethindrone, was developed by organic chemist Carl Djerassi in Syntex Laboratories in Mexico City. Djerassi was developing a synthetic progestin for menstrual irregularities. His product turned out to be a powerful inhibitor of ovulation, but he had not anticipated that the estrogen-with-progestin combination oral contraceptive pill (COCP) would have other effects upon women. Only after many years was this combination suspected as the culprit in many unexpected side-effects, including blood clots, diabetes, depression and anxious emotional states experienced by women.

That some of these side-effects can be serious is confirmed by a new report of conclusive evidence for significant loss of bone mineral densitywhen a woman uses Depo-Provera (a long-acting injectable form of a progestin-only contraceptive) for more than two years.

In 2005, the International Agency for Research on Cancer (IARC), an arm of the World Health Organization, estimated that worldwide more than 100 million women were using some form of COCP. In developed countries, the current usage was estimated at 16 percent, while the “ever used” rate was as high as 80%. Although there appeared to be extreme variability between countries, the evaluation found that most contraceptives were used by women of younger age and with higher educational achievement.

After an earlier evaluation, the IARC had classified oral contraceptives as a Group 1 carcinogen: “There is sufficient evidence in humans for the carcinogenicity of combined oral estrogen-progestogen contraceptives,” it said in 1999. The weight of evidence indicated an increased risk for breast cancer, which was greater for women who were under age 35 at the time of diagnosis and who had begun using contraceptives before their 20th birthday. This was reaffirmed by the 2005 review.

In 2006 the Mayo Clinic Proceedings published a meta-analysis of 23 studies done in several countries about breast cancer risk and use of oral contraceptives. Dr Chris Kahlenborn, one of the principal authors, stated that “if a woman takes combined oral contraceptive pills before her first full-term pregnancy, she risks a 44% increased chance of developing pre-menopausal breast cancer when compared to women who have never taken an OCP.” Kahlenborn also found that “if a woman takes OCPs for 4 years or more prior to her first full-term pregnancy, she suffers a 52% increased risk.”

Kahlenborn also uncovered that the commonly used contraceptive Depo-Provera was reported by the WHO and a New Zealand study to be associated with a statistically significant 190% increased risk for breast cancer when Depo-Provera was taken by a woman for more than 3 years prior to the age of 25.

Drinking Water Contamination

In 2002, the US Geological Survey found one or more pharmaceuticals in 80% of the streams it had tested. In 2006 the Los Angeles Times reported that sewage contained traces of medications like antibiotics, anti-depressants, birth-control hormones, Viagra, Valium and heart drugs. Shane Snyder, lead toxicologist at the Southern Nevada Water Authority, said, “There is no place on Earth exempted from having pharmaceuticals and steroids in its wastewater. This is clearly an issue that is global, and we are going to see more and more of these chemicals in the environment, no doubt about it.”

The Potomac Conservancy found similar drinking water conditions in Washington, DC. Mirroring other regions of the country where biologists have found frogs contaminated with Prozac, insects on anti-seizure drugs and algae killed by antibiotics, the waterways draining the Shenandoah Mountains and tributaries flowing into the Potomac River have witnessed fish kills since 2002. The unexpected observation was that most of the dead male fish had inter-sex characteristics and that there was a disproportionate number of female fish. Further examination by the US Geological Survey of the Potomac tributaries revealed that 80% of the male fish had the inter-sex condition.

Although the concentrations of some of the pharmaceuticals found in drinking water sources, including estrogens and fertility drugs, are in the parts per trillion, comparable to putting a few drops in an Olympic-sized pool, the effects this may have on humans remains unknown. What is known is that on the level of endocrine systems, fish and humans function in very similar ways. What happens to fish may be signaling future disorders for humans.

Contraceptives: A Form of Endocrine Disrupting Chemicals

In 2009, the world’s leading professional association for endocrinologists, the Endocrine Society, issued a strong statement on endocrine-disrupting chemicals. The evidence suggests that exposure to multiple endocrine disrupting chemicals at developmental stages has the potential to affect any hormone-sensitive body systems, including the breast and the hypothalamic-pituitary-ovarian system in women, and the testes and prostate gland in men. The Endocrine Society appealed to the precautionary principle stating, “This principle is key to enhancing endocrine and reproductive health, and should be consulted to inform decisions about exposure to and risk from any potential endocrine disruptor.” And, “The public may be placed at risk because critical information about potential health effects of endocrine disrupting chemicals to which Americans are exposed is being overlooked in the development of federal guidelines and regulations.”

The Pill’s Link to STDs

Are there any strong associations between use of steroid-based OCPs and sexually transmitted diseases? The CDC’s answer is yes. A review of 83 studies published in the journal Contraception in 2006 found that the use of combined oral contraceptives and Depo-Provera generally had a positive association with cervical chlamydial infections. Chlamydia infections and other inflammatory STDs such as syphilis or genital herpes are reported by the CDC to increase the risk for transmission of Human Immunodeficiency Virus (HIV) infection. Chlamydia is well-known as the leading preventable infection that can cause a severe condition called Pelvic Inflammatory Disease (PID), which if not treated, can result in female infertility.

The recent STD report for 2008 from the CDC stated that adolescent girls between the ages of 15-19 account for 27% of the total new cases of Chlamydia and gonorrhea. Although acknowledging that adolescent boys have a similar prevalence of STDs, the CDC insisted that because of “biological differences” young women have a greater potential to suffer consequences to their health than young men.

Depressing Sex

What was most surprising to Dr. Meg Meeker, pediatrician and adolescent medicine specialist, was her observation that many of her adolescent female patients who had begun to engage in sexual encounters were showing signs of clinical depression. In her book, “Strong Fathers, Strong Daughters” (2007), she said, “Kids get depressed when they experience a loss for which they cannot express a healthy emotion. This is very common with sexual activity. When a girl has sex, she loses her virginity and very often loses her self-respect with it.”

This clinical observation of one pediatrician is supported by findings of researchers interested in any association between teenage sexual experimentation, drug use and depression. Denise Hallfors and colleagues found that for girls even modest involvement in sexual experimentation or substance use elevated depression risk. In contrast, boys exhibited little added risk of depression with sexual experimental behavior, although binge drinking and frequent use of marijuana contribute substantial risk.

Thanatos Syndrome Revisited

In Walker Percy’s 1987 novel The Thanatos Syndrome, Dr. Tom More returns to his home town and family to restart what remains of his practice of psychiatry after serving a felony conviction for selling prescriptions for narcotics. After a few weeks of re-establishing contact with some of his former patients, he notices a profound change in his patients, with unusual mood changes, increased ability to recall the location of obscure names of places and the ability to make complex numeric calculations. In addition, his patients all seem to have become hyper-eroticized, exhibiting outlandish sexual advances that persons with intact higher-order self-control would recognize as outside the range of socially acceptable behavior.

He postulated that something had changed his patients. With the help of an epidemiologist, More learned that toxic, radioactive sodium had been released from a nearby nuclear power plant and that the water with the heavy sodium was being deliberately channeled through an unauthorized and hidden pipe into the drinking water supply. Behind this scheme were some of More’s medical colleagues, who discovered that dosing the water supply with low concentrations of heavy sodium had the effect of suppressing the cognitive functioning of antisocial types like alcoholics, drug addicts, prostitutes or those confined to the local jail. The docs felt justified in what they were doing. They wanted Dr. Tom to join them when they discovered he knew their tactics. But, Dr. Tom knew better.

It appears that for the last 50 years, something similar has been happening to America. The contraceptive pill was sold as the scientific panacea for ultimate sexual liberation. Its real-time effect has been a form of “lobotomy” of reason and good judgment, both of users and prescribers. It is time the medical establishment recognized its complicity and returned to the simple principle for which it gained the respect and autonomy of action it merited as an advocate for the unprotected and unknowing: “Above all, do no harm.”

This article was originally published by the online journal  "".